pentobarbital will lower the extent or effect of verapamil by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep track of.pentobarbital will reduce the extent or impact of midostaurin by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Prevent or Use Alternate Drug. Powerful CYP3A4 inducers might minimize midostaurin